Creatine Supplementation Alleviates Fatigue after Exercise through Anti-Inflammatory Action in Skeletal Muscle and Brain

Eccentric exercise induces muscle damage and inflammation, resulting in a state of reduced physical activity with dysfunction feeling tiredness after exercise. Creatine is known to act as an energy buffer, but it has also been suggested exert inhibitory effects on peripheral inflammation. The purpose this study was test the hypothesis that creatine supplementation alleviates fatigue eccentric explore mechanism effect. C57BL/6J mice were fed AIN-93G-formulated control diet or creatine-containing for 6 days then subjected downhill running, model exercise, assess total concentrations skeletal brain tissue, spontaneous activity, urine concentration titin N-fragment, inflammatory gene expression. results showed significantly increased tissue. Furthermore, decreased running maintained higher level activity. In addition, suppressed downhill-running-induced increase mRNA expression genes encoding ICAM-1, E-selectin, CD18, BKB1R soleus IL-1β hypothalamus. On other hand, did not clearly influence N-fragment. These indicate may alleviate by partially suppressing inflammation slow-twitch